Brendan Rodgers is expected to welcome back captain Steven Gerrard to the side after he missed the last four games for Liverpool.
Joe Allen and Mamadou Sakho both picked up knocks during the defeat to Chelsea and are both expected to be out for a number of games.
Victor Moses is available again after sitting out the Chelsea game due to them being his parent club.
Steve Bruce will be without some key players for the trip to Merseyside. David Meyler has been ruled out along with Robbie Brady, Sone Aluko, Stephen Quinn.
Danny Graham could earn a recall to the starting lineup as could Alex Bruce.